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1

Reaction-based Enumeration, Active Learning, and Free Energy Calculations to Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-dependent Kinase 2 Inhibitors

Konze, Kyle, Bos, Pieter H., Dahlgren, Markus K., Leswing, Karl, Brohman, Ivan Tubert, Bortolato, Andrea, Robbason, Braxton, Abel, Robert, Bhat, Sathesh

Journal:

Journal of Chemical Information and Modeling

Year:

2019

Language:

english

File:

PDF, 6.04 MB

english, 2019

2

Combining Cloud-Based Free Energy Calculations, Synthetically Aware Enumerations and Goal-Directed Generative Machine Learning for Rapid Large Scale Chemical Exploration and Optimization

Ghanakota, Phani, Bos, Pieter H., Konze, Kyle, Staker, Joshua, Marques, Gabriel, Marshall, Kyle, Leswing, Karl, Abel, Robert, Bhat, Sathesh

Journal:

Journal of Chemical Information and Modeling

Year:

2020

File:

PDF, 8.44 MB

2020

3

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Konze, Kyle D., Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin, Christopher J., Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie, Marie, Jiang, Alice, Patte

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 4.35 MB

english, 2013

4

Inside Cover: A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a (ChemMedChem 3/2014)

Konze, Kyle D., Pattenden, Samantha G., Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Simon, Jeremy M., Davis, Ian J., Vedadi, Masoud, Jin, Jian

Journal:

Year:

2014

File:

PDF, 1.35 MB

2014

5

A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a

Konze, Kyle D., Pattenden, Samantha G., Liu, Feng, Barsyte-Lovejoy, Dalia, Li, Fengling, Simon, Jeremy M., Davis, Ian J., Vedadi, Masoud, Jin, Jian

Journal:

Year:

2014

Language:

english

File:

PDF, 645 KB

english, 2014

6

Selective Inhibitors of Protein Methyltransferases

Kaniskan, H. Ümit, Konze, Kyle D., Jin, Jian

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 6.59 MB

english, 2015

7

Targeting EZH2 and PRC2 dependence as novel anticancer therapy

Xu, Bowen, Konze, Kyle D., Jin, Jian, Wang, Gang Greg

Journal:

Experimental Hematology

Year:

2015

Language:

english

File:

PDF, 7.80 MB

english, 2015

8

Structure–Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors

Yang, Xiaobao, Li, Fengling, Konze, Kyle D., Meslamani, Jamel, Ma, Anqi, Brown, Peter J., Zhou, Ming-Ming, Arrowsmith, Cheryl H., Kaniskan, H. Ümit, Vedadi, Masoud, Jin, Jian

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.75 MB

english, 2016